Egyptian Journal of Dermatology and Venerology

ORIGINAL ARTICLE
Year
: 2018  |  Volume : 38  |  Issue : 1  |  Page : 12--17

Association of proinflammatory cytokine tumor necrosis factor-α gene promoter -308 and -238 polymorphism with psoriasis in North Indian population


Wani Aadil1, Bashir Ahmad Ganai2, Tahseena Akhtar3, Tarun Narang4, Rajinder Kaur3 
1 Department of Human Genetics, Punjabi University, Patiala, Punjab; Department of Biochemistry, University of Kashmir, Srinagar, Jammu and Kashmir, India
2 Center of Research for Development (CORD), University of Kashmir, Srinagar, Jammu and Kashmir, India
3 Department of Human Genetics, Punjabi University, Patiala, Punjab, India
4 Department of Dermatology, Venereology and Leprology, Post Graduate Institute of Medical Education and Research, Chandigarh, India

Correspondence Address:
Rajinder Kaur
Department of Human Genetics, Punjabi University, Patiala, Punjab
India

Background/objective Tumor necrosis factor (TNF) is an important proinflammatory cytokine that plays a role in the pathogenesis of psoriasis. The aim of the present study was to investigate the role of TNF-α −308G/A and TNF-α −238G/A polymorphism, haplotype, and serum level in the pathogenesis of psoriasis. Materials and methods A total of 200 psoriatic patients and 200 controls were genotyped for TNF-α −308G/A and TNF–α −238G/A polymorphism by using polymerase chain reaction. In addition, serum levels of TNF-α were measured by enzyme-linked immunosorbent assay. Results Polymorphism of TNF–α −308 was found to be associated with a decreased risk for psoriasis odds ratio=0.29; (95% confidence interval=0.14–0.62), and polymorphism of TNF–α −238 was associated with an increased risk for psoriasis odds ratio=37.81; (95% confidence interval=12.77–112.01). HT2 GA haplotype was found to be associated with an increased risk for psoriasis. Moreover, the serum TNF-α level increased in patients compared with controls, with a significant correlation between serum TNF-α and psoriasis severity. Conclusion Our findings suggested that TNF-α polymorphisms imparted significant risk toward the development of psoriasis in north Indian population.


How to cite this article:
Aadil W, Ganai BA, Akhtar T, Narang T, Kaur R. Association of proinflammatory cytokine tumor necrosis factor-α gene promoter -308 and -238 polymorphism with psoriasis in North Indian population.Egypt J Dermatol Venerol 2018;38:12-17


How to cite this URL:
Aadil W, Ganai BA, Akhtar T, Narang T, Kaur R. Association of proinflammatory cytokine tumor necrosis factor-α gene promoter -308 and -238 polymorphism with psoriasis in North Indian population. Egypt J Dermatol Venerol [serial online] 2018 [cited 2018 Oct 20 ];38:12-17
Available from: http://www.ejdv.eg.net/article.asp?issn=1110-6530;year=2018;volume=38;issue=1;spage=12;epage=17;aulast=Aadil;type=0