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ORIGINAL ARTICLE
Year : 2020  |  Volume : 40  |  Issue : 1  |  Page : 1-8

The relationship between the levels of interleukin-17 and 25-hydroxyvitamin D in vitiligo outcome


1 Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Zagazig University, Zagazig, Egypt
2 Department of Clinical Pathology, Faculty of Medicine, Zagazig University, Zagazig, Egypt

Correspondence Address:
MD Fathia M Khattab
Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Zagazig University, Egypt
Egypt
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ejdv.ejdv_29_18

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Background The active form of vitamin D (1,25 hydroxyvitamin D) mediates the interaction between vitamin D and immune diseases including vitiligo, which was found to be associated with lower 25(OH)D levels. Objective To evaluate the role of vitamin D and interleukin (IL)-17 in vitiligo and its relationship with autoimmune diseases and to assess the therapeutic effect of vitamin D in patients with vitiligo. Patients and methods A total of 44 patients with vitiligo were measured for vitamin D and IL-17. Those with a low level of vitamin D took vitamin D droplet for 3 months and were then re-evaluated with Vitiligo European Task Force score before and after treatment. Results A significant negative correlation was found between vitamin D and IL-17 levels. A statistically significant increase in vitamin D level and decrease in IL-17 level was seen after treatment when compared with before treatment, accompanied by improvement of Vitiligo European Task Force scoring values after treatment. Conclusion The use of systemic vitamin D as a treatment modality for vitiligo can achieve reasonable improvement comparable to traditional modalities.


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