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Year : 2015  |  Volume : 35  |  Issue : 2  |  Page : 49-55

Risks for metabolic syndrome and cardiovascular diseases in both male and female patients with androgenetic alopecia

Department of Dermatology and Venereology, Faculty of Medicine, Alexandria University, Alexandria, Egypt

Correspondence Address:
Naglaa Agamia
MD, PhD, Department of Dermatology and Venereology, Faculty of Medicine, Alexandria University, Alexandria
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/1110-6530.178459

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Background Androgenetic alopecia (AGA) is a nonscarring progressive miniaturization of the hair follicle with a usually characteristic pattern of distribution in genetically predisposed men and women. Although several previous studies have investigated the association of metabolic syndrome (MS) and cardiovascular risks with AGA, the results have been inconsistent. Aim We attempted to evaluate the possible association between MS and cardiovascular risks with AGA in both male and female patients. This may help to detect whether AGA can be considered as a clue for underlying serious systemic diseases. Patients and methods A total of 50 patients (38 male and 12 female) and 50 normal sex-matched and age-matched controls were included. Anthropometric measures, blood pressure, fasting glucose, high-density lipoprotein cholesterol, triglycerides, testosterone, sex hormone binding globulin, and serum insulin levels were evaluated. Acute phase reactants (C-reactive protein, fibrinogen, and erythrocyte sedimentation rate) were measured for all participants. The presence of MS, insulin resistance, and cardiovascular risk factors were evaluated. Results There were statistically significant differences with regard to the mean values of waist circumference, BMI, systolic blood pressure, fasting blood sugar, fibrinogen, and Homeostasis Model Assessment of Insulin Resistance in both male and female patients. In contrast, triglycerides, cholesterol, MS, erythrocyte sedimentation rate, and sex hormone binding globulin were significantly elevated in male patients only in relation to their sex-matched controls. Conclusion Patients of both sexes with AGA are more susceptible to have cardiovascular diseases in future compared with people who do not have AGA.

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